Job Description

Summary:

We are seeking a highly motivated and skilled individual to join our Antibody Discovery team as Scientist I. T his open position is an exciting opportunity to impact the next wave of biologic candidates to enter our pipeline. The successful candidate should have general in vitro antibody display experience with special emphasis on yeast display though candidates with any display technology experience are encouraged to apply. The ideal candidate will work to optimize a yeastdisplay discovery platform and participate in antibody library design and construction. They will collaborate with scientists from different functional groups and conduct in vitro display campaigns to identify novel therapeutic hits and optimize leads against a wide range of targets and diseases. Candidates should have a demonstrated record of technical proficiency and the ability to work effectively with a diverse group of researchers in a team environment.

Job Duties Include:

• Perform yeast and phage displaybased discovery screens to support new and ongoing therapeutic programs.
  
• Use NGS including NGS library generation QC sequencing and data analysis for hit selection.
  
• Execute displaybased lead optimization including design and building of new display libraries QC and screening.
  
• Stay current with external advancements in relevant scientific fields and techniques.
  
• Evaluate scientific strategies review data in realtime and make the necessary experimental adjustments to ensure successful delivery of yeast display discovery campaigns.
  
• Coordinate research & development efforts with other departments to prioritize critical experiments for advancing discovery programs.
  
• Participate and present data in group and departmental meetings as needed.
  
• Follow all laboratory safety guidelines practices and protocols.
  
• Contribute to the design and execution of experiments analysis interpretation of data and reporting and archiving of results.
  
• Adhere to all department and companywide policies regarding conduct performance and procedures.
  
• May provide direction to direct and indirect reports as applicable in accordance with the organization s policies and procedures.
  
• Attend to daily laboratory operations including the maintenance of equipment inventories consumables reagents and other supplies.
  

Education/Experience/Skills:

• Position requires a Ph.D. in a relevant scientific field with at least 1year postgraduate laboratory work experience preferred.
  
• Also requires sound theoretical and experimental experience in a relevant scientific field coupled with technical proficiency scientific creativity collaboration with others and independent thought.
  
• Small company and industry work experience preferred.
  
• Strong handson experience with phage and/or yeast display including building na ve and/or immunized libraries.
  
• Experience with antibody lead optimization including affinity potency and developability enhancement.
  
• Expertise in molecular cloning and utilization of DNA analysis software (Geneious Prime Sequencher or similar software).
  
• Experience in NGS technology including NGS library generation QC sequencing and sequence analysis.
  
• Experience with AI / ML sequence analysis preferred.
  
• Strong understanding of antibody structure function and engineering.
  
• Experience with high throughput screening (96 and 384well plates) and liquid handling automation is desirable.
  
• Onsite presence with time split between lab (80%) and nonlab activities (20%).
  
• Excellent verbal and written communication skills; ability to communicate clearly and effectively with scientific colleagues and management by contributing sound scientific concepts ideas and direction.
  
• Significant analytical assessment and problemsolving skills.
  
• Ability to perform method development write protocols maintain detailed records and use an electronic notebook are required.
  
• Experience with Benchling as an ELN and database is desirable.
  
• Ability to read analyze interpret and communicate complex data and information.
  
• Proficiency in software and data analysis packages like Microsoft Office (Word Excel Outlook PowerPoint) and GraphPad Prism.
  
• Ability to effectively collaborate coach and mentor others through scientific and technical communication.
  
• Ability to work in a fastpaced goaloriented multiproject environment with adaptability to changing priorities and capacity to excel working on a team and individually is required.
  
• Strong organizational and interpersonal skills attention to detail and professional competencies in oral and written communication are required.
  
• May contribute to authoring of scientific documents as needed.
  

Physical Mental and Environment Demands:

• The working environment includes a research laboratory which may involve running experiments and operating laboratoryscale process equipment for sample and data generation.
  
• Occasionally repetitive tasks prolonged standing and the use of PPE for handling hazardous and biohazardous materials may be required.
  
• Office environment includes extended time sitting and using office equipment including a computer keyboard and mouse which can cause muscle strain.
  
• The employee is frequently required to stand walk and sit with periodic light lifting of supplies and materials.
  
• Ability to multitask without loss of efficiency or accuracy.
  
• Ability to work and sustain attention with distractions and/or interruptions.
  
• Ability to interact appropriately with various individuals including vendors customers and clients.
  

Additional Requirements for Laboratory and Research Related Jobs:

• Ability to follow the established Environmental Health & Safety rules procedures and/or BioSafety Guidelines.
  
• Ability to read and understand Safety Data Sheets (SDSs).
  
• Ability to be available and willing to work some weekends and evenings to conduct and complete experiments.
  
• Knowledge of biosafety techniques and aseptic/gowning practices.
  
• Experience with laboratory safety standards and procedures including biohazard handling and disposal techniques and the ability to ensure laboratory compliance with required safety regulations.
  
• Experience working with biological and chemical hazards infectious agents bloodborne pathogens and animal allergens.
  
• Experience working in and maintaining a sterile environment.
  
• Thorough knowledge of the operation and maintenance of various lab equipment such as microscopes centrifuges spectrophotometers balances pH meters electrophoresis equipment freezers and incubators.
  

Requirements Bachelor s degree in a scientific field (biology, chemistry, nursing, or pharmacy preferred). At least 12 years of experience in clinical trial management, including 8 years in a leadership role and 5 years of people management. Experience in biotech or pharma industries, particularly with autoimmune indications such as Irritable Bowel Disease or Ulcerative Colitis, preferred. Expert knowledge of FDA/EMEA regulations, ICH guidelines, and GCPs. Strong time management, organizational, and problem-solving skills. Proficiency in Microsoft Outlook, Word, PowerPoint, and Project. Demonstrated ability to manage and develop team members effectively.

Job Tags

Work experience placement, Weekend work, Afternoon shift,

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